2,4-Dichloroacetophenone has the general chemical properties of acetophenone, and the carbonyl group can undergo addition, reduction and other reactions. Since there are two chlorine atoms on the benzene ring, it has certain chemical activity and can undergo nucleophilic substitution reactions. The chlorine atom can be replaced by other groups. For example, under alkaline conditions, the chlorine atom can be replaced by hydroxyl, amino and the like.
Features
Melting Point
33-34°C (lit.)
Boiling Point
140-150°C 15mm Hg (lit.)
Density
1.32
Flash point
>230°F
Form
Solid
Packaging
25KG Bag
Application
2,4-Dichloroacetophenone is the raw material for preparing ω-bromo-2,4-dichloroacetophenone or ω-2,4-trichloroacetophenone. The latter two are intermediates for preparing fungicides such as imazalil, propiconazole, and ethiconazole, as well as intermediates for insecticides such as chlorfenapyr and herbicides such as diazinon.
2,4-Dichloroacetophenone is an important organic synthesis intermediate, which is used to synthesize a variety of drugs, pesticides, spices and other organic compounds. For example, it can be used as an intermediate for synthesizing drugs for the treatment of cardiovascular diseases, as well as some pesticide intermediates with insecticidal and fungicidal activity.
Used as a pharmaceutical intermediate for the synthesis of ketoconazole.
In pharmaceutical research and development, its derivatives may have certain biological activities and can be used as lead compounds for structural modification and optimization to develop new drugs.
Precautions
2,4-Dichloroacetophenone is irritating to the eyes, skin, and respiratory tract. Contact should be avoided during use. If it accidentally comes into contact with the eyes or skin, rinse immediately with plenty of water and seek medical treatment.
It should be stored in a sealed container in a cool, dry, well-ventilated place, away from sources of fire and oxidants.
Frequently Asked Questions (FAQ)
What is the primary chemical function of 2,4-Dichloroacetophenone?
It serves as an important organic synthesis intermediate, specifically utilized in the preparation of active drug ingredients, agricultural pesticides, fragrances, and other specialized organic compounds.
Which pesticides and fungicides are derived from 2,4-Dichloroacetophenone?
It is a key starting material for producing intermediates like ω-bromo-2,4-dichloroacetophenone and ω-2,4-trichloroacetophenone, which are essential in synthesizing fungicides (imazalil, propiconazole, ethiconazole), insecticides (chlorfenapyr), and herbicides (diazinon).
What are the physical specifications, such as melting and boiling points?
2,4-Dichloroacetophenone is a solid substance with a melting point of 33-34°C and a boiling point of 140-150°C at 15mm Hg. Its density is 1.32.
Are there any specific medical or pharmaceutical uses for it?
Yes, it is used as a pharmaceutical intermediate to synthesize ketoconazole. Additionally, its derivatives are utilized as lead compounds in drug research and development, particularly for cardiovascular therapies.
What are the storage requirements for 2,4-Dichloroacetophenone?
It must be stored inside a tightly sealed container and placed in a cool, dry, and well-ventilated location. Ensure it is kept far away from any open flame, heat sources, and oxidants.
Saier Chemical
