Shandong Saier Chemical provides a robust spectrum of high-grade solvents and industrial chemical building blocks, optimized for high-capacity global supply lines.
Deuterated Acetone (chemically known as Acetone-d6, CAS Number: 666-89-7) represents an indispensable tool in modern scientific discovery. As a fully deuterated isotopic isomer of acetone, it acts as a standard solvent in nuclear magnetic resonance (NMR) spectroscopy. By replacing all six hydrogen atoms with deuterium isotopes ($(CD_3)_2CO$), NMR analytical labs can prevent large proton background signals, allowing clean detection of solute proton configurations.
In global analytical frameworks, the purity of Acetone-d6 directly corresponds to the resolution limits of NMR measurement equipment. With a characteristic deuteration index of up to 99.9%, it offers absolute signal clarity, a feature relied upon heavily by biomedical developers, pesticide laboratories, and university research clinics globally. Furthermore, its physical properties, such as a boiling point of 55.5°C and high solubility for both polar and non-polar compounds, make it a premier choice for analytical operations.
Founded in December 2004, Shandong Saier Chemical Technology Development Co., Ltd. is a recognized national high-tech enterprise, strategically located in the renowned Qilu Chemical Industrial Park, Linzi, Zibo City, Shandong Province. With a registered capital of 60 million yuan and an annual production capacity reaching 720,000 tons, the company has positioned itself as an industry benchmark in intermediate chemistry, fine chemistry materials, and high-boiling aromatic solvents.
Through long-term strategic relationships with global petrochemical enterprises like Sinopec, PetroChina, ChemChina, Zhejiang Petrochemical, and Hengli Petrochemical, Shandong Saier Chemical ensures continuous access to high-grade raw materials. The company's diversified portfolio includes aromatic solvents S100 through S200, intermediate materials like 2',4'-dichloroacetophenone, Beta-Methylnaphthalene, and advanced laboratory solvents, serving domestic markets and exporting to Asia, Europe, the Americas, and Southeast Asia.
Situated inside the Qilu Chemical Industrial Park, our facilities leverage deep regional logistical channels, integrated pipeline networks, and instant bulk material access.
We maintain comprehensive ISO 9001, ISO 14001, and REACH certification, guaranteeing that every export shipment is cleared through strict GHS and international trade regulations.
Continuous investment in catalytic deuterium exchange mechanisms and purification optimization ensures that our Acetone-d6 stands tall against traditional Western competitors.
Achieving ultra-high deuteration levels requires rigorous chemical pathways and advanced industrial equipment. The primary synthetic production of Acetone-d6 involves base-catalyzed hydrogen-deuterium exchange between high-purity acetone ($(CH_3)_2CO$) and deuterium oxide ($D_2O$). Because the reaction is reversible, it is run in multiple sequential batches to systematically push the isotopic equilibrium towards the deuterated state.
| Synthesis Stage | Key Process Parameters | Technological Target | Impurities Addressed |
|---|---|---|---|
| 1. Initial Deuterium Exchange | Base-catalyzed (using inorganic Deuteroxides), excessive D2O cycles | Replace >95% of active Hydrogen atoms with Deuterium | Residual non-deuterated Acetone (H6) |
| 2. Multi-stage Distillation | Low-pressure vacuum rectification, temperature controls | Partitioning solvent from deuterium water residue | Deuterium Oxide (D2O), heavy water leftovers |
| 3. Chemical Dehydration | Recirculation over anhydrous molecular sieves / calcium oxide | Reduce overall water index below 300 ppm (0.03%) | Trace H2O / atmospheric humidity ingress |
| 4. Cryogenic Inert Bottling | Ultra-dry Argon/Nitrogen shielding, amber borosilicate glass | Prevent isotopic dilution from ambient humidity during storage | Protonation from atmospheric moisture |
Through this advanced engineering approach, Shandong Saier Chemical provides a solution that minimizes residual H2O/D2O peaks in NMR spectra. Uncontrolled water content creates broad, overlapping proton peaks (typically around 2.8 ppm in deuterated acetone), masking the chemical shifts of analyte compounds.
Deuterated acetone is a critical reagent across various industrial domains, extending far beyond academic laboratory settings. In our capacity as a leading supplier, Shandong Saier Chemical provides customized solutions tailored to specific commercial applications:
In drug design, identifying molecular structures is critical for FDA and international compliance filings. Pharmaceutical developers use high-purity Acetone-d6 to verify synthesized active pharmaceutical ingredients (APIs). Its low residual water content ensures that analytical NMR signals are not obscured.
During the manufacturing of Organic Light Emitting Diodes (OLEDs), deuterated compounds are synthesized to replace weaker carbon-hydrogen (C-H) bonds with stronger carbon-deuterium (C-D) bonds. This modification extends the functional lifespan and degradation threshold of OLED screens.
Developing environmentally sustainable pesticides and herbicides requires continuous molecular tracing. Acetone-d6 serves as a stable solvent for monitoring target compounds throughout agricultural degradation testing and environmental impact assessments.
Many global buyers struggle with trace impurities and moisture contamination in deuterated solvents. At Shandong Saier Chemical, we address these challenges through our strict Quality Assurance protocol:
Addressing the key operational and technical questions from procurement officers and laboratory directors.
Explore our broader selection of specialty chemical intermediates, aromatic solvents, and high-purity syntheses developed under strict quality management.
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